CE 0459

Biocoral® is perfectly tolerated by the human body with no risk of contamination and is compatible with the structural requirements of bone growth.

Biocoral® has an excellent bone integration with total resorption between 3 to 9 months.

Biocoral® because of its mineral and architectural characteristics (Aragonite Crystal and Porosity) once placed in bony sites, is quickly impregnated with autogenous blood or bone marrow, with a proved calcification from the day 9th.

Biocoral® has an ideal porosity which allows a quick invasion of bone marrow and integration of newly formed bone.

Re-initiates Bone Mineralization Process
Biocoral® is used as an active ingredient for reinitiating the process of bone remineralization (See Indication).

Replaced by Newly Formed Bone
Biocoral® is quickly vascularized and progressively resorbed by osteoclast cells, which is then replaced by osteoblast cells in order to conduct newly formed bone identical to the recipient bone6.

No Risk of Viral Transfer Nor Other Contamination
Biocoral® follows strict quality control procedures which are performed at each stage of manufacturing process and guarantees its compliance with high quality standards and offers surgeons a truly trustworthy biomaterial.

Easy to Use
Biocoral® is available in a variety of shapes (granules, beads, blocks and shaped protheses) and sizes, it is easily used and applied in the surgical site once infiltrated by autogenous blood or bone marrow.

Effective Cost
Biocoral® is the best alternative to autografts, minimizing patient’s hospitalizations and its health care costs..


Biocoral® is a biomaterial  containing Calcium Carbonate (>98%)  derived from Natural Coral and is used as a bone graft substitute Biocoral® ensures a BONE REGENERATION by its affinity to bone cells and its interconnected porosity similar to cancellous bone.

Biocoral® is the only natural wholly mineral bone graft substitute having a highly porous architecture, which is formed from naturally occurring aragonite crystal with three-dimensional interconnectivity allowing for optimum formation of new bone.

Chemical Composition

Biocoral® is constituted of over 98% Calcium carbonate in the crystalline form (Aragonite)


Several components are present at levels equivalent to those found in mammalian bone, notably trace elements, which play a vital role in the process of mineralization and in the activation of enzymatic reactions in bone cells.
Two trace elements have specifics effects:
Strontium is involved in the formation and growth of the crystalline component of bone, protects calcification mechanisms and increasesmineralization. Furthermore, Strontium levels are higher in the most active bone structure the metaphysis and bone callus.
Fluorine in proper quantity increases bone formation by direct effects on proliferation of cellular precursors of osteoblasts.


-   Natural Calcium Carbonate (CaCO3),
-   3 dimensional randomly  interconnected pore,
-   Pore size: 150µm,
-   Porosity: 50% allowing an ideal newly bone formation.


The porosity architecture of Biocoral® is in the form of aragonite crystalline. The regular structures of pores, their volume, their size and the thickness of their walls are the special characteristics of Biocoral®. The open porosity of Biocoral®, allows the blood cells and bone marrow cells (blood, anions, cations, etc...) to spread and infiltrate in its core which speed up the bone ingrowths. Biocoral® present the remarkable mechanical resistance qualities associated to its porosity (50% and 20%) similar to those of the cancellous and cortical bone respectively.

The natural choice for new bone growth

Biocoral® is biocompatible and safe
The perfect biocompatibility of Biocoral® has been demonstrated by standardized studies realized in vitro and in vivo and has been confirmed in all human clinical indications for bone substitution and bone regeneration.
Biocoral® safety is appropriate for all indicated use and there is No risk of virus transmission by the product).

Biocoral® is bioactive.
Biocoral® because of its unique activity and dune only to its mineral and architectural characteristics (Aragonite Crystal and Porosity), once placed is bony sites is quickly impregnated with autogenous blood or bone marrow, with a proved calcification from the day 9th.
Experiments show the attraction of bone cells by Biocoral® and the early bone formation directly in contact to Biocoral®.



Phase 1: Invasion by blood cells and extravasated bone marrow.

Phase 2: Vascularization (v: vessels).

Phase 3: Resorption of Biocoral® by osteoclasts (oc: osteoclast).

Phase 4: Bone neoformation with osteoblastic (ob: osteoblast) apposition and concomitant resorption.

Phase 5: Remodeling of neoformed tissue to produce the architecture of the recipient bone.

Biocoral® bioactivity, together with its osteoconductive and osteophilic properties, induces specific biological activity in the recipient bone, similar to the physiological natural bone metabolism. This activity leads to graduate resorption of Biocoral® by osteoclasts and its replacement by osteoblasts in newly formed bone.

The natural POROSITY

Biocoral® porosity is similar to cancellous bone. The volume, organization and regularity of pores support the bone cells invasion, the implant stabilization, vascularization and bone formation.

The "natural" strength
Biocoral® 50% porosity is at least 5 times stronger than cancellous bone and biocoral 20% porosity is at least as strong as fresh cortical bone.

Biocoral® is resorbed progressively and replaced by neoformed bone.
Resorption of the calcium carbonate skeleton of Biocoral® is due to the enzyme content (carbonic anhydrase) released by the osteoclasts.

Biocoral® is a natural ceramic of calcium carbonate supporting the mineralisation of the neoformed bone by liberating its natural mineral elements.

 Section of Biocoral® 50% porosity 



Section of Human femural cortex


Section of human cancellous bone



Section of Biocoral®


General Information



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